Important It is possible that the main title of the report Acquired Aplastic Anemia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
idiopathic aplastic anemia
Summary Acquired aplastic anemia is a rare disorder caused by profound, almost complete bone marrow failure. Bone marrow is the spongy substance found in the center of the bones of the body, in adults mainly the spine, pelvis, and large bones of the legs. The bone marrow produces specialized cells (hematopoietic stem cells) that grow and eventually develop into red blood cells (erythrocytes), white blood cells (leukocytes), and platelets. In acquired aplastic anemia, an almost complete absence of hematopoietic stem cells eventually results in low levels of red and white blood cells and platelets (pancytopenia). Specific symptoms associated with acquired aplastic anemia may vary, but include fatigue, chronic infections, dizziness, weakness, headaches, and episodes of bleeding, usually in the skin and mucous membranes. Although some cases of acquired aplastic anemia occurs secondary to other disorders, researchers now believe that most cases result from a disorder of the patient's immune system, which mistakenly targets the bone marrow (autoimmunity). This is based on the response of the majority of patients to immunotherapy, whether it is ATG and cyclosporine, high-dose corticosteroids or cyclophosphamide.
Introduction Aplastic anemia is classified as severe according to blood counts. Most of the discussion that follows relates to severe aplastic anemia. Patients with more moderately decreased blood counts; may not require treatment. Furthermore, some aplastic anemia that is genetically inherited may, first manifest in adulthood, without a family history of blood disease.
Aplastic Anemia & MDS International Foundation, Inc. 100 Park Avenue, Suite 108 Rockville, MD 20850 USA Tel: (301)279-7202 Fax: (301)279-7205 Tel: (800)747-2820 Email: firstname.lastname@example.org Internet: http://www.aamds.org
NIH/National Heart, Lung and Blood Institute P.O. Box 30105 Bethesda, MD 20892-0105 Tel: (301)592-8573 Fax: (301)251-1223 Email: email@example.com Internet: http://www.nhlbi.nih.gov/
Aplastic Anemia & Myelodysplasia Association of Canada 11181 Yonge Street Suite 321 Richmond Hill Ontario, L4S 1L2 Canada Tel: 9057800698 Fax: 9057801648 Tel: 8888400039 Email: firstname.lastname@example.org Internet: http://www.aamac.ca
NIH/National Heart, Lung and Blood Institute ~ Hematology Branch 10 Center Dr, Building 10-CRC 3-5140, MSC-1202 Bethesda, MD 20892-1202 Tel: (301)496-5093 Fax: (301)496-8396 Tel: (800)644-2337 Email: YoungNS@mail.nih.gov Internet: http://dir.nhlbi.nih.gov/labs/hb/index.asp?
Dubowitz Syndrome Support c/o 106 Verndale Street Warwick, RI 02889-3242 USA Tel: (401)737-3138 Email: email@example.com Internet: http://www.dubowitzsyndrome.net
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
Madisons Foundation PO Box 241956 Los Angeles, CA 90024 Tel: (310)264-0826 Fax: (310)264-4766 Email: firstname.lastname@example.org Internet: http://www.madisonsfoundation.org
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