Important It is possible that the main title of the report Eisenmenger Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Eisenmenger syndrome is a rare progressive heart condition that develops in some individuals with structural malformations of the heart that are present from birth (congenital heart defects). The disorder is characterized by increased blood pressure in the main blood vessel (pulmonary artery) connecting the heart to the lungs (pulmonary hypertension) and improper blood flow within the heart.
The normal heart has four chambers. The two upper chambers, known as atria, are separated from each other by a fibrous partition known as the atrial septum. The two lower chambers are known as ventricles and are separated from each other by the ventricular septum. Valves connect the atria (left and right) to their respective ventricles. The valves allow for blood to be pumped through the chambers. Blood travels from the right ventricle through the pulmonary artery to the lungs where it receives oxygen. The blood returns to the heart through pulmonary veins and enters the left ventricle. The left ventricle sends the now oxygen-filled blood into the main artery of the body (aorta). The aorta sends the blood throughout the body.
The most common congenital heart defect associated with Eisenmenger syndrome is a ventricular septal defect (VSD) or a "hole in the heart" between the two lower chambers of the heart (left ventricle and right ventricle. This defect allows blood to flow from the left ventricle into the right ventricle (left-to-right shunt). The shunt causes increased blood flow into the lungs eventually resulting in pulmonary hypertension, which causes progressive damage to the small blood vessels in lungs (pulmonary vascular disease). As the damage continues, pulmonary hypertension increases and the small blood vessels become thickened or blocked hampering the flow of blood. Ultimately, blood flow is reversed back through the shunt so that blood flows from the right ventricle into the left ventricle (right-to-left shunt) bypassing the lungs completely. A variety of symptoms including life-threatening complications may occur.
Eisenmenger syndrome specifically refers to the combination of pulmonary hypertension and right-to-left shunting of the blood within the heart.
March of Dimes Birth Defects Foundation 1275 Mamaroneck Avenue White Plains, NY 10605 Tel: (914)997-4488 Fax: (914)997-4763 Tel: (888)663-4637 Email: Askus@marchofdimes.com Internet: http://www.marchofdimes.com
American Heart Association 7272 Greenville Avenue Dallas, TX 75231 Tel: (214)784-7212 Fax: (214)784-1307 Tel: (800)242-8721 Email: Review.firstname.lastname@example.org Internet: http://www.heart.org
National Transplant Assistance Fund 150 N. Radnor Chester Road Suite F-120 Radnor, PA 19087 USA Tel: (610)353-9684 Fax: (610)535-6106 Tel: (800)642-8399 Email: NTAF@transplantfund.org Internet: http://www.transplantfund.org
National Foundation For Transplants 5350 Poplar Ave Suite 430 Memphis, TN 38119 USA Tel: (901)684-1697 Fax: (901)684-1128 Tel: (800)489-3863 Email: email@example.com Internet: http://www.transplants.org
NIH/National Heart, Lung and Blood Institute P.O. Box 30105 Bethesda, MD 20892-0105 Tel: (301)592-8573 Fax: (301)251-1223 Email: firstname.lastname@example.org Internet: http://www.nhlbi.nih.gov/
American Organ Transplant Association 21175 Tomball Parkway 194 Houston, TX 77070 Tel: (713)344-2402 Fax: (713)344-9422 Email: email@example.com Internet: http://www.aotaonline.org
Second Wind Lung Transplant Association, Inc. P.O. Box 1657 Wimberley, TX 78676-1657 USA Tel: (512)847-9303 Tel: (888)855-9463 Email: firstname.lastname@example.org Internet: http://www.2ndwind.org
Kids With Heart ~ National Association for Children's Heart Disorders, Inc. 1578 Careful Dr. Green Bay, WI 54304 Tel: (920)498-0058 Fax: (920)498-0058 Tel: (800)538-5390 Email: email@example.com Internet: http://www.kidswithheart.org
Little Hearts, Inc. P.O. Box 171 110 Court Street, Suite 3A Cromwell, CT 06416 USA Tel: (860)635-0006 Fax: (860)635-0006 Tel: (866)435-4673 Email: firstname.lastname@example.org Internet: http://www.littlehearts.org
Congenital Heart Information Network (C.H.I.N.) P.O. Box 3397 Margate City, NJ 08402-0397 Tel: (609)823-4507 Fax: (609)822-1574 Email: email@example.com Internet: http://www.tchin.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
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