Important It is possible that the main title of the report Autoimmune Polyendocrine Syndrome Type II is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Diabetes Mellitus, Addison's Disease, Myxedema
Multiple Endocrine Deficiency Syndrome, Type II
Polyglandular Autoimmune Syndrome, Type II
Polyglandular Deficiency Syndrome, Type II
Autoimmune polyendocrine syndrome type II, also known as Schmidt syndrome, is a rare autoimmune disorder in which there is a steep drop in production of several essential hormones by the glands that secrete these hormones. When first described, this disorder was thought to involve only adrenal insufficiency (Addison's disease) and thyroid insufficiency (Hashimoto's thyroiditis). However, over time, as more patients were studied, the scope of the disorder was expanded to include disorders of other underperforming endocrine glands. These include the gonads, which secrete sex hormones; the pancreas which secretes insulin and is intimately tied up with diabetes mellitus; and sometimes the parathyroid glands. Failure of the endocrine glands to function is usually accompanied by signs of malnutrition because the ability of the intestinal tract to absorb nutrients is reduced dramatically. Since the combination of affected glands differs from patient to patient, the signs of this disorder are diverse.
Most cases of this disorder are sporadic although some clinical researchers believe that there is a familial or hereditary trait associated with AIPS-II. If so, it may involve a complex interaction among many genes.
Myasthenia Gravis Foundation of America 355 Lexington Ave 15th Floor New York, NY 10017-6603 Tel: (212)297-2156 Fax: (212)370-9047 Tel: (800)541-5454 Email: email@example.com Internet: http://www.myasthenia.org
National Adrenal Diseases Foundation 505 Northern Bloulevard Great Neck, NY 11021 USA Tel: (516)487-4992 Fax: (516)829-5710 Email: firstname.lastname@example.org Internet: http://www.nadf.us/
American Autoimmune Related Diseases Association, Inc. 22100 Gratiot Ave. East Detroit, MI 48021 Tel: (586)776-3900 Fax: (586)776-3903 Tel: (800)598-4668 Email: email@example.com Internet: http://www.aarda.org/
Celiac Sprue Association P.O. Box 31700 Omaha, NE 68131-0700 USA Tel: (402)558-0600 Fax: (402)643-4108 Tel: (877)272-4272 Email: firstname.lastname@example.org Internet: http://www.csaceliacs.org
American Diabetes Association 1701 N. Beauregard Street Alexandria, VA 22311 Tel: (703)549-1500 Fax: (703)549-6995 Tel: (800)342-2383 Email: askADA@diabetes.org Internet: http://www.diabetes.org
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Last Updated: 7/23/2007 Copyright 1991, 1996, 2005, 2007 National Organization for Rare Disorders, Inc.
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