Important It is possible that the main title of the report WAS Related Disorders is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Wiskott Aldrich syndrome
X-linked congenital neutropenia
The WAS-related disorders are a spectrum of conditions affecting the immune system that are caused by mutations in the WAS gene. These disorders include Wiskott-Aldrich syndrome, X-linked thrombocytopenia and X-linked congenital neutropenia. The WAS gene abnormality results in a deficiency in the WASP protein that leads to a low platelet count (thrombocytopenia). WAS-related disorders usually present in infancy and are characterized by bloody diarrhea, recurrent infections, scaling, itchy, skin rashes (eczema), and the appearance of small purple spots on the skin (petechia). The development of Pneumocystis carinii pneumonia (PCP) and intracranial bleeding are possible early, life-threatening complications. Later potential complications include destruction of red blood cells (hemolytic anemia), arthritis, vasculitis and kidney and liver damage. Affected individuals have an increased risk of developing lymphomas, especially after exposure to Epstein-Barr virus. WAS-related disorders are extremely variable, even in individuals in the same family.
March of Dimes Birth Defects Foundation 1275 Mamaroneck Avenue White Plains, NY 10605 Tel: (914)997-4488 Fax: (914)997-4763 Tel: (888)663-4637 Email: Askus@marchofdimes.com Internet: http://www.marchofdimes.com
Immune Deficiency Foundation 40 W. Chesapeake Avenue Suite 308 Towson, MD 21204 Tel: (410)321-6647 Fax: (410)321-9165 Tel: (800)296-4433 Email: firstname.lastname@example.org Internet: http://www.primaryimmune.org
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse One AMS Circle Bethesda, MD 20892-3675 USA Tel: (301)495-4484 Fax: (301)718-6366 Tel: (877)226-4267 TDD: (301)565-2966 Email: NIAMSinfo@mail.nih.gov Internet: http://www.niams.nih.gov/
NIH/National Heart, Lung and Blood Institute P.O. Box 30105 Bethesda, MD 20892-0105 Tel: (301)592-8573 Fax: (301)251-1223 Email: email@example.com Internet: http://www.nhlbi.nih.gov/
NIH/National Institute of Allergy and Infectious Diseases Office of Communications and Government Relations 6610 Rockledge Drive, MSC 6612 Bethesda, MD 20892-6612 Tel: (301)496-5717 Fax: (301)402-3573 Tel: (866)284-4107 TDD: (800)877-8339 Email: firstname.lastname@example.org Internet: http://www.niaid.nih.gov/
Center for International Blood and Marrow Transplant Research Froedtert and the Medical College of Wisconsin Clinical Cancer Center 9200 W. Wisconsin Avenue Milwaukee, WI 53226 Tel: (414)805-0700 Fax: (414)805-0714 Email: email@example.com Internet: http://www.cibmtr.org/
American Academy of Allergy, Asthma and Immunology 611 East Wells Street Milwaukee, WI 53202 Tel: (414)272-6071 Fax: (414)276-3349 Tel: (800)822-2762 Email: firstname.lastname@example.org Internet: http://www.aaaai.org
National Bone Marrow Transplant Link 20411 W. 12 Mile Rd Suite 108 Southfield, MI 48076 Tel: (248)358-1886 Fax: (248)358-1889 Tel: (800)546-5268 Email: email@example.com Internet: http://www.nbmtlink.org
International Patient Organization for Primary Immunodeficiencies Firside Main Road Downderry Cornwall, PL11 3LE United Kingdom Tel: 441503250668 Fax: 441503250961 Email: firstname.lastname@example.org Internet: http://www.ipopi.org/
Jeffrey Modell Foundation 780 Third Avenue New York, NY 10017 USA Tel: (212)819-0200 Fax: (212)764-4180 Tel: (866)469-6474 Email: email@example.com Internet: http://www.info4pi.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
European Society for Immunodeficiencies 1-3 rue de Chantepoulet Geneva, CH 1211 Switzerland Tel: 410229080484 Fax: 41229069140 Email: firstname.lastname@example.org Internet: http://www.esid.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 2/15/2008 Copyright 1986, 1987, 1988, 1993, 1996, 1997, 1998, 1999, 2006, 2007, 2008 National Organization for Rare Disorders, Inc.
How this information was developed to help you make better health decisions.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.