Corneal dystrophies are a group of genetic, often progressive, eye disorders in which abnormal material often accumulates in the clear (transparent) outer layer of the eye (cornea). Corneal dystrophies may not cause symptoms (asymptomatic) in some individuals; in others they may cause significant vision impairment. The age of onset and specific symptoms vary among the different forms of corneal dystrophy. The disorders have some similar characteristics - most forms of corneal dystrophy affect both eyes (bilateral), progress slowly, do not affect other areas of the body, and tend to run in families. Most forms are inherited as autosomal dominant traits; a few are inherited as autosomal recessive traits.
An international classification of the corneal dystrophies has been developed that takes into account the chromosomal loci of the various corneal dystrophies as well as the responsible genes and their mutations. Traditionally, these disorders have classified based upon their clinical findings and the specific layer of the cornea affected. Advances in molecular genetics (e.g., identification of specific disease genes) have led to a greater understanding of these disorders.
Lighthouse International 111 E 59th St New York, NY 10022-1202 Tel: (800)829-0500 Email: email@example.com Internet: http://www.lighthouse.org
Eye Bank Association of America 1015 18th Street, NW Suite 1010 Washington, DC 20036 Tel: (202)775-4999 Fax: (202)429-6036 Email: firstname.lastname@example.org Internet: http://www.restoresight.org
NIH/National Eye Institute 31 Center Dr MSC 2510 Bethesda, MD 20892-2510 United States Tel: (301)496-5248 Fax: (301)402-1065 Email: email@example.com Internet: http://www.nei.nih.gov/
Pediatric Keratoplasty Association c/o Gerald Zaidman, M.D. Westchester Medical Center Department of Ophthalmology Valhalla, NY 10595 Tel: (914)493-1599 Fax: (914)493-7445 Email: firstname.lastname@example.org Internet: http://www.pedkera.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
Boston Foundation for Sight 464 Hillside Ave. Suite 205 Needham, MA 02494 Tel: (781)726-7337 Fax: (781)726-7310 Email: email@example.com Internet: http://www.bostonsight.org
Corneal Dystrophy Foundation 6066 McAbee Rd. San Jose, CA 95120 USA Fax: (408)490-2775 Tel: (866)807-8965 Email: firstname.lastname@example.org Internet: http://www.cornealdystrophyfoundation.org
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Last Updated: 6/30/2010 Copyright 1988, 1989, 2002, 2010 National Organization for Rare Disorders, Inc.
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