Important It is possible that the main title of the report Refractory Sprue is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
refractory celiac disease
intractable celiac sprue
type I refractory sprue
type II refractory sprue
Refractory sprue (RS) is a complex autoimmune disorder much like the more common celiac sprue but, unlike celiac sprue, it is resistant or unresponsive to six months of treatment with a strict gluten-free diet. Gliadin, a component of the wheat storage protein gluten, together with similar proteins in barley and rye, are the villains that trigger the immune reaction in celiac sprue. The diagnosis of RS is made by exclusion, especially of any other disorder that can affect the huge number of thread-like projections that line the interior of the intestine (intestinal villi), such as intestinal lymphoma, Crohn's disease, small intestinal bacterial overgrowth or hypogammaglobulinemia.
The intestinal villi are the means by which the gut absorbs fluids and nutrients. In celiac sprue and refractory sprue, these villi shrink and shrivel (atrophy) affecting the absorption of nutrients via the intestines. In celiac sprue, treatment by means of a strict gluten-free diet is usually sufficient to overcome the disorder. However, refractory sprue is just that: refractory or stubbornly resistant to treatment. Only a small percentage of the people with celiac sprue will develop RS, and these patients are almost invariably 30 years of age or older. However, as yet, it is impossible to predict which patient of those with celiac sprue will develop RS.
Association of Gastrointestinal Motility Disorders, Inc. 12 Roberts Drive Bedford, MA 01730 Tel: (781)275-1300 Fax: (781)275-1304 Email: firstname.lastname@example.org Internet: http://www.agmd-gimotility.org
Gluten Intolerance Group of North America 31214 124th Ave SE Auburn, WA 98092 Tel: (253)833-6655 Fax: (253)833-6675 Email: email@example.com Internet: http://www.gluten.net
Crohn's and Colitis Foundation of America 386 Park Avenue South 17th Floor New York, NY 10016-7374 USA Tel: (212)685-3440 Fax: (212)779-4098 Tel: (800)932-2423 Email: firstname.lastname@example.org Internet: http://www.ccfa.org
Celiac Sprue Association P.O. Box 31700 Omaha, NE 68131-0700 USA Tel: (402)558-0600 Fax: (402)643-4108 Tel: (877)272-4272 Email: email@example.com Internet: http://www.csaceliacs.org
NIH/National Institute of Diabetes, Digestive & Kidney Diseases Office of Communications & Public Liaison Bldg 31, Rm 9A06 31 Center Drive, MSC 2560 Bethesda, MD 20892-2560 Tel: (301)496-3583 Email: NDDIC@info.niddk.nih.gov Internet: http://www2.niddk.nih.gov/
International Foundation for Functional Gastrointestinal Disorders 700 W. Virginia St., 201 Milwaukee, WI 53217 USA Tel: (414)964-1799 Fax: (414)964-7176 Tel: (888)964-2001 Email: firstname.lastname@example.org Internet: http://www.iffgd.org
Celiac Disease Foundation 20350 Ventura Blvd Ste 240 Woodland Hills, CA 91364 USA Tel: (818)716-1513 Fax: (818)267-5577 Email: email@example.com Internet: http://www.celiac.org
Academy of Nutrition and Dietetics 120 South Riverside Plaza, Suite 2000 Chicago, IL 60606-6995 Tel: (312)899-0400 Fax: (312)899-4899 Tel: (800)877-1600 Email: firstname.lastname@example.org Internet: http://www.eatright.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
National Foundation for Celiac Awareness P.O. Box 544 224 South Maple Street Ambler, PA 19002 Tel: (215)325-1306 Fax: (215)643-1707 Email: email@example.com Internet: http://www.CeliacCentral.org
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
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Last Updated: 2/7/2013 Copyright 2006, 2010, 2013 National Organization for Rare Disorders, Inc.
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