Anthrax is a serious, sometimes deadly disease caused by infection with anthrax bacteria.
These bacteria produce
spores that can spread the infection.
Anthrax in humans is rare unless the spores are spread on purpose. It became a concern in the United States in 2001, when 22 cases occurred as a result of bioterrorism. Most of those cases
affected postal workers and media employees who were exposed to spores
when handling mail.
Most cases of anthrax occur in livestock, such as cattle, horses, sheep, and goats. Anthrax spores in the soil can infect animals who eat plants growing in the soil. People can be exposed to spores in infected animal products or meat. This is not much of a concern in North America, because livestock are vaccinated against anthrax. But people can get anthrax from handling animal skins or products made out of animal skins from parts of the world where anthrax is more common.
What causes anthrax?
Anthrax is caused by Bacillus anthracis bacteria. There are three types of infection:
Cutaneous (skin) anthrax. This can occur when spores enter your body through a break in the
skin. Half of the cases in the
2001 U.S. terrorist attacks were this type.1
Inhalational (lung) anthrax. This can occur when you breathe in spores. It is the most serious type of infection. Half of the cases in the 2001 attacks were
Gastrointestinal (digestive) anthrax. This can occur when you eat food contaminated with anthrax spores. This has occurred in developing regions of Asia, the Middle East, and Africa, but not in North America.
The illness does not seem to spread from person to person. People who come in contact with someone who has anthrax don't need to be immunized or treated unless they were exposed to the same source of infection.
What are the symptoms?
symptoms and the incubation period—the time from exposure to anthrax
until symptoms start—depend on the type of infection you have.
With cutaneous anthrax, symptoms usually appear 5 to 7 days after exposure to spores, though it may take longer.
The first symptom may be a small, raised bump that might itch.
becomes a painless, fluid-filled blister and later forms a black center of dying tissue.
Swollen lymph nodes, headache, and
fever also may occur.
With inhalational anthrax, symptoms usually appear 1 to 7 days after exposure. (But it can take as long as 60 days).
At first you may feel like you have the flu, with a sore throat, a mild fever, and muscle aches. But you may also have shortness of breath, which is not common with the flu.3
Severe trouble breathing, high fever, and shock may occur 1 to 5 days later.
Death usually follows within a day or two.
With gastrointestinal anthrax, symptoms usually occur within a week after exposure.
At first you may have mouth ulcers, a sore throat, trouble swallowing, loss of appetite, vomiting, or a fever.
As the illness gets worse, you may have trouble breathing (because of swelling in the throat), bloody diarrhea or vomit, or belly pain caused by fluid buildup.
death may follow within a few days.
How is anthrax diagnosed?
Your doctor will ask you questions about your symptoms and about any work or other activities that may have put you at risk for exposure. If the doctor suspects you may have been exposed to anthrax, testing will be done to confirm exposure or infection. Public health officials also will be notified about a possible anthrax infection.
Anthrax is confirmed when the bacteria are identified from a
culture of your blood, spinal
fluid, skin sores, or mucus from your nose, airways, or lungs. If
results of a culture aren't clear, you may need other blood tests or a polymerase chain reaction (PCR) test. A skin ulcer may be biopsied.
If your doctor thinks that you have inhalational anthrax, you
may have a chest
X-ray or a
How is it treated?
Antibiotics are used to treat all types of anthrax.
Anyone who is infected needs to be treated with antibiotics as soon as possible. Starting treatment before symptoms begin may make the illness less severe and prevent death. Treatment may also include supportive care in the hospital.
Anyone who has been exposed to anthrax spores but is not infected should be treated with antibiotics and a few doses of the vaccine to prevent infection. Not everyone who has been exposed to anthrax will
get sick. But because there's no way to know who will get sick and who won't, anyone who is directly exposed will get treatment. If you think that you have been exposed, call your local law enforcement agency and your doctor right away. Don't take antibiotics without talking to your doctor first.
Can anthrax be prevented?
In the U.S., the anthrax vaccine(What is a PDF document?) is used to protect only the small number of people who are at higher risk for exposure. These include:
Some military personnel.
Some lab workers.
Some people who come in contact with animals from other countries.
The vaccine is not
available to the general public at this time. The risk of exposure to anthrax is extremely low.
The bioterrorism attacks in 2001 made many people nervous about opening their mail. If you receive a piece of mail that contains a powdery
substance or seems suspicious, the U.S. Centers for Disease Control and Prevention (CDC) recommends that you put down the piece of mail and not touch it again. Then, leave the room, wash your hands with soap and water, and call 911 to find out what to do next.
If you have concerns about anthrax, you can find the most current information through the CDC (http://emergency.cdc.gov/agent/anthrax).
Centers for Disease Control and Prevention (CDC):
Emergency Preparedness and Response
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Atlanta, GA 30333
This Web site is intended to help people living in the
United States of America prepare for and respond to public health emergencies.
You can report an emergency, find information on the top emergency resources,
and learn practical tips such as how to assemble an emergency supply kit.
This Web site also has information on bioterrorism, chemical and
radiation emergencies, mass casualties, natural disasters and severe weather,
and recent outbreaks and incidents.
National Institute of Allergy and Infectious Diseases
(NIAID), National Institutes of Health
NIAID Office of Communications and Government Relations
6610 Rockledge Drive, MSC 6612
Bethesda, MD 20892-6612
The National Institute of Allergy and Infectious
Diseases conducts research and provides consumer information on infectious and
U.S. Food and Drug Administration (FDA)
10903 New Hampshire Avenue
Silver Spring, MD 20993-0002
The U.S. Food and Drug Administration (FDA) is an agency within the Department of Health and Human Services. The FDA provides accurate, science-based information about medicines and foods and helps protect public health by assuring the safety, effectiveness, and security of:
Southwick FS (2010). Infections due to Gram-positive bacilli. In EG Nabel, ed., ACP Medicine, section 7, chap. 4. Hamilton, ON: BC Decker.
Inglesby TV, et al. (2002). Anthrax as a biological weapon, 2002: Updated recommendations for management. JAMA, 287(17): 2236–2252.
Centers for Disease Control and Prevention (2001). Considerations for distinguishing influenza-like illness from inhalational anthrax. MMWR, 50(44): 985–987.
Other Works Consulted
American Public Health Association (2008). Anthrax. In DL Heymann, ed., Control of Communicable Diseases Manual, 19th ed., pp. 22–31. Washington, DC: American Public Health Association.
Duchin J, Malone JD (2009). Anthrax section of Bioterrorism. In EG Nabel, ed., ACP Medicine, section 8, chap. 5, pp. 8–16. Hamilton, ON: BC Decker.
Martin GJ, Friedlander AM (2010). Bacillus anthracis (anthrax). In GL Mandell et al., eds., Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed., vol. 2, pp. 2715–2725. Philadelphia: Churchill Livingstone Elsevier.
Shadomy SV, Rosenstein NE (2008). Anthrax. In RB Wallace et al., eds., Wallace/Maxcy-Rosenau-Last Public Health and Preventive Medicine, 15th ed., pp. 1185–1194. New York: McGraw-Hill.
Primary Medical Reviewer
E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer
W. David Colby IV, MSc, MD, FRCPC - Infectious Disease
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