Important It is possible that the main title of the report Beckwith Wiedemann Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Beckwith-Wiedemann syndrome (BWS) is a rare genetic overgrowth disorder. It is characterized by a wide spectrum of symptoms and physical findings that vary in range and severity from case to case. However, in many individuals, associated features include above-average birth and weight and increased growth after birth (postnatally), an usually large tongue (macroglossia), enlargement of certain internal organs (visceromegaly), and protrusion of a portion of the intestines and abdominal organs through a tear in the wall of the stomach or bellybutton (abdominal wall defects). BWS may also be associated with low blood sugar levels within the first few days or the first month of life (neonatal hypoglycemia), advanced bone age, particularly up to age four; distinctive grooves in the ear lobes and other facial abnormalities, abnormal enlargement of one side or structure of the body (hemihyperplasia) may occur, resulting in unequal (asymmetric) growth, and an increased risk of developing certain childhood cancers.
In approximately 85 percent of cases, BWS results from genetic changes that appear to occur randomly (sporadically). Approximately 10-15 percent of cases of this syndrome run in families and show autosomal dominant inheritance. Researchers have determined that BWS results from various abnormalities affecting the proper expression or structure of certain genes within a specific region of chromosome 11.
March of Dimes Birth Defects Foundation 1275 Mamaroneck Avenue White Plains, NY 10605 Tel: (914)997-4488 Fax: (914)997-4763 Tel: (888)663-4637 Email: Askus@marchofdimes.com Internet: http://www.marchofdimes.com
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American Childhood Cancer Organization 10920 Connecticut Ave Suite A Kensington, MD 20895 Tel: (301)962-3520 Fax: (301)962-3521 Tel: (800)366-2223 Email: firstname.lastname@example.org Internet: http://www.candlelighters.org
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Neuroblastoma Children's Cancer Society P.O. Box 957672 Hoffman Estates, IL 60195 USA Tel: (847)605-1245 Fax: (847)605-0705 Tel: (800)532-5162 Email: Info@neurblastomacancer.org Internet: http://www.neuroblastomacancer.org
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CureSearch for Children's Cancer 4600 East West Highway, Suite 600 Bethesda, MD 20814-3457 USA Tel: (626)447-1674 Fax: (626)447-6359 Tel: (800)458-6223 Email: email@example.com Internet: http://www.curesearch.org
NIH/National Institute of Child Health and Human Development 31 Center Dr Building 31, Room 2A32 MSC2425 Bethesda, MD 20892 Fax: (866)760-5947 Tel: (800)370-2943 TDD: (888)320-6942 Email: NICHDInformationResourceCenter@mail.nih.gov Internet: http://www.nichd.nih.gov/
Beckwith-Wiedemann Family Forum 105 Yehudah St. Apt 2 Modi'in, 71700 Israel Tel: 01197289714544 Email: firstname.lastname@example.org Internet: http://www.beckwith-wiedemann.info/
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
Beckwith-Wiedemann Children's Foundation 9031 Cascadia Ave Everett, WA 98208 Tel: (425)338-4610 Fax: (425)357-8575 Email: BWCFKathy@comcast.net Internet: http://www.beckwith-wiedemannsyndrome.org
Hemihypertrophy Support 4581 Magnolia Dr. Suffolk, VA 23435 Tel: (757)615-3686 Email: email@example.com Internet: http://www.hemisupport.com
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