Important It is possible that the main title of the report Gastroparesis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
gastrointestinal autonomic neuropathy
delayed gastric emptying
severe functional dyspepsia
Gastroparesis (abbreviated as GP) represents a clinical syndrome characterized by sluggish emptying of solid food (and more rarely, liquid nutrients) from the stomach, which causes persistent digestive symptoms especially nausea and primarily affects young to middle-aged women, but is also known to affect younger children and males. Diagnosis is made based upon a radiographic gastric emptying test. Diabetics and those acquiring gastroparesis for unknown (or, idiopathic) causes represent the two largest groups of gastroparetic patients; however, numerous etiologies (both rare and common) can lead to a gastroparesis syndrome.
Gastroparesis is also known as delayed gastric emptying and is an old term that does not adequately describe all the motor impairments that may occur within the gastroparetic stomach. Furthermore, there is no expert agreement on the use of the term, gastroparesis. Some specialists will reserve the term, gastroparesis, for grossly impaired emptying of the stomach while retaining the label of delayed gastric emptying, or functional dyspepsia (non-ulcer dyspepsia), for less pronounced evidence of impaired emptying. These terms are all very subjective. There is no scientific basis by which to separate functional dyspepsia from classical gastroparesis except by symptom intensity. In both conditions, there is significant overlap in treatment, symptomatology and underlying physiological disturbances of stomach function.
For the most part, the finding of delayed emptying (gastric stasis) provides a "marker" for a gastric motility problem. Regardless, the symptoms generated by the stomach dysmotility greatly impair quality of life for the vast majority of patients and disable about 1 in 10 patients with the condition.
While delayed emptying of the stomach is the clinical feature of gastroparesis, the relationship between the degree of delay in emptying and the intensity of digestive symptoms does not always match. For instance, some diabetics may exhibit pronounced gastric stasis yet suffer very little from the classical gastroparetic symptoms of: nausea, vomiting, reflux, abdominal pain, bloating, fullness, and loss of appetite. Rather, erratic blood-glucose control and life-threatening hypoglycemic episodes may be the only indication of diabetic gastroparesis. In another subset of patients (diabetic and non-diabetic) who suffer from disabling nausea that is to the degree that their ability to eat, sleep or carry out activities of daily living is disrupted gastric emptying may be normal, near normal, or intermittently delayed. In such cases, a gastric neuro-electrical dysfunction, or gastric dysrhythmia (commonly found associated with gastroparesis syndrome), may be at fault.
Therefore, these disorders of functional dyspepsia, gastric dysrhythms, and gastroparesis are all descriptive labels sharing similar symptoms and perhaps representing a similar entity of disordered gastric neuromuscular function. For this reason, a more encompassing term, gastropathy, can be used interchangeably with gastroparesis.
Association of Gastrointestinal Motility Disorders, Inc. 12 Roberts Drive Bedford, MA 01730 Tel: (781)275-1300 Fax: (781)275-1304 Email: email@example.com Internet: http://www.agmd-gimotility.org
American Diabetes Association 1701 N. Beauregard Street Alexandria, VA 22311 Tel: (703)549-1500 Fax: (703)549-6995 Tel: (800)342-2383 Email: askADA@diabetes.org Internet: http://www.diabetes.org
Digestive Disease National Coalition 507 Capitol Court, NE Suite 200 Washington, DC 20002 Tel: (202)544-7497 Fax: (202)546-7105 Email: firstname.lastname@example.org Internet: http://www.ddnc.org
NIH/National Institute of Diabetes, Digestive & Kidney Diseases Office of Communications & Public Liaison Bldg 31, Rm 9A06 31 Center Drive, MSC 2560 Bethesda, MD 20892-2560 Tel: (301)496-3583 Email: NDDIC@info.niddk.nih.gov Internet: http://www2.niddk.nih.gov/
International Foundation for Functional Gastrointestinal Disorders 700 W. Virginia St., 201 Milwaukee, WI 53217 USA Tel: (414)964-1799 Fax: (414)964-7176 Tel: (888)964-2001 Email: email@example.com Internet: http://www.iffgd.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
International Scleroderma Network 7455 France Ave So #266 Edina, MN 55435-4702 Tel: (952)583-5735 Tel: (800)564-7099 Email: firstname.lastname@example.org Internet: http://www.sclero.org
Gastroparesis & Dysmotilities Association 5520 Dalhart Hill N.W. Calgary, AB, T3A 1S9 Canada Tel: 4032473215 Email: email@example.com Internet: http://www.digestivedistress.com
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Last Updated: 3/16/2012 Copyright 2009, 2012 National Organization for Rare Disorders, Inc.
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