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Albumin Urine Test

Albumin Urine Test

Test Overview

An albumin test checks urine for the presence of a protein called albumin . Albumin is normally found in the blood and filtered by the kidneys. When the kidneys are working properly, albumin is not present in the urine. But when the kidneys are damaged, small amounts of albumin leak into the urine. This is called albuminuria.

Albuminuria is most often caused by kidney damage from diabetes . But many other conditions can lead to kidney damage, such as high blood pressure , heart failure , cirrhosis , or systemic lupus erythematosus (SLE) . If early kidney damage is not treated, larger amounts of albumin and protein may leak into the urine. When the kidneys spill protein, it can mean serious kidney damage is present. This can lead to chronic kidney disease . An albumin urine test can be done on a sample of urine collected randomly (usually after the first time you urinate in the morning), a sample collected over a 24-hour period, or a sample collected over a specific period of time, such as 4 hours or overnight.

Why It Is Done

An albumin urine test is done to check for protein (albumin) in the urine. Early detection may change treatment in an effort to preserve as much kidney function as possible.

How To Prepare

You do not need to do anything before having this test.

How It Is Done

For a random urine test, you will provide a clean-catch midstream urine sample. A morning urine sample gives the best information about albumin levels.

Clean-catch midstream one-time urine collection

This collection method prevents contamination of the sample.

  • Wash your hands to make sure they are clean before collecting the urine.
  • If the collection cup has a lid, remove it carefully and set it down with the inner surface up. Do not touch the inside of the cup with your fingers.
  • Clean the area around your genitals.
    • A man should pull back the foreskin, if present, and clean the head of his penis thoroughly with medicated towelettes or swabs.
    • A woman should spread open the folds of skin around her vagina with one hand, then use her other hand to clean the area around her vagina and urethra thoroughly with medicated towelettes or swabs. She should wipe the area from front to back to avoid contaminating the urethra with bacteria from the anus .
  • Begin urinating into the toilet or urinal. A woman should continue to hold apart the folds of skin around the vagina while she urinates.
  • After the urine has flowed for several seconds, place the collection cup into the stream and collect about 2 fl oz (60 mL) of this "midstream" urine without interrupting the flow.
  • Do not touch the rim of the cup to your genital area, and do not get toilet paper, pubic hair, stool (feces), menstrual blood, or other foreign matter in the urine sample.
  • Finish urinating into the toilet or urinal.
  • Carefully replace the lid on the cup and return it to the lab. If you are collecting the urine at home and cannot get it to the lab in an hour, refrigerate it.

A urine sample collected over time, such as over 4 or 24 hours, gives the most accurate results so you may be asked to collect your urine over a specific time period.

Timed urine collection (24 hours)

  • You start collecting your urine in the morning. When you first get up, empty your bladder but do not save this urine. Write down the time that you urinated to mark the beginning of your 24-hour collection period.
  • For the next 24 hours, collect all your urine. Your doctor or lab will usually provide you with a large container that holds about 1 gal (4 L). The container has a small amount of preservative in it. Urinate into a small, clean container and then pour the urine into the large container. Do not touch the inside of either container with your fingers.
  • Keep the large container in the refrigerator for the 24 hours.
  • Empty your bladder for the final time at or just before the end of the 24-hour period. Add this urine to the large container and record the time.
  • Do not get toilet paper, pubic hair, stool (feces), menstrual blood, or other foreign matter in the urine sample.

How It Feels

There is no discomfort while collecting a urine sample.

Risks

There is no chance of problems while collecting a urine sample.

Results

An albumin test checks urine for the presence of a protein called albumin . This is called albuminuria, and it is most often caused by kidney damage from diabetes .

The normal values listed here—called a reference range—are just a guide. These ranges vary from lab to lab, and your lab may have a different range for what's normal. Your lab report should contain the range your lab uses. Also, your doctor will evaluate your results based on your health and other factors. This means that a value that falls outside the normal values listed here may still be normal for you or your lab.

Albumin in urine
One-time collection:

Less than 2 milligrams per liter (mg/L) 1

24-hour collection:

Adults at rest: Less than 80 milligrams (mg) in 24 hours or 0.002–0.08 grams (g) per day 2

Adults moving around: Less than 150 mg in 24 hours or less than 0.15 g per day 2

10-hour (overnight) collection:

Less than 20 milligrams per liter (mg/L) for 10-hour (overnight) collection 3

 

Higher-than-normal values

You may need more than one test to find out how well your kidneys are working.

  • If your results are higher than normal, your doctor may check your urine more often to watch for kidney damage.
  • If you have 2 or 3 high results in a 3- to 6-month period and you have diabetes, your doctor may find kidney damage ( diabetic nephropathy ). Even though diabetes is the most common reason for high results, there are many other kidney problems that can cause high results.

Pregnant women with diabetes may have their urine checked to watch for high amounts of albumin.

What Affects the Test

Reasons you may not be able to have the test or why the results may not be helpful include:

  • Having high blood sugar levels, urinary tract infections, high blood pressure, heart failure, or a high fever during an infection.
  • Exercising just before the test.
  • Taking medicines, such as aspirin, corticosteroids , or some antibiotics , such as amoxicillin.
  • Having menstrual bleeding or vaginal discharge, which may temporarily affect the urine sample.

What To Think About

  • The American Diabetes Association recommends three tests to check for kidney damage. These tests are blood pressure, urine albumin, and a creatinine blood test to calculate an estimated glomerular filtration rate (eGFR). Creatinine is a waste product that is filtered out of the blood by healthy kidneys. To learn more, see the topic Creatinine and Creatinine Clearance.
    • If you have type 2 diabetes, you should have these tests when you are first diagnosed, and then each year to check for diabetic nephropathy.
    • If you have type 1 diabetes, you should have these tests to check for diabetic nephropathy each year starting 5 years after diagnosis.
    • If you have either type of diabetes and are pregnant, talk to your doctor about how often you need to be tested.
  • A less precise test, the urine dipstick test, can be used to check for albumin in a single sample of urine. But the dipstick test does not accurately detect albuminuria and is not recommended in place of an albumin urine test.

References

Citations

  1. Pagana KD, Pagana TJ (2010). Mosby’s Manual of Diagnostic and Laboratory Tests, 4th ed. St. Louis: Mosby Elsevier.
  2. Chernecky CC, Berger BJ (2008). Laboratory Tests and Diagnostic Procedures, 5th ed. St. Louis: Saunders.
  3. Fischbach FT, Dunning MB III, eds. (2009). Manual of Laboratory and Diagnostic Tests, 8th ed. Philadelphia: Lippincott Williams and Wilkins.

Other Works Consulted

  • American Diabetes Association (2014). Standards of medical care in diabetes—2014. Diabetes Care, 37(Suppl 1): S14–S80. DOI: 10.2337/dc14-S014. Accessed January 7, 2014.
  • Chernecky CC, Berger BJ (2008). Laboratory Tests and Diagnostic Procedures, 5th ed. St. Louis: Saunders.
  • Fischbach FT, Dunning MB III, eds. (2009). Manual of Laboratory and Diagnostic Tests, 8th ed. Philadelphia: Lippincott Williams and Wilkins.
  • Pagana KD, Pagana TJ (2010). Mosby’s Manual of Diagnostic and Laboratory Tests, 4th ed. St. Louis: Mosby Elsevier.

Credits

By Healthwise Staff
Primary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer Michael Mallea, MD - Nephrology
Current as of January 28, 2014

Current as of: January 28, 2014

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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