Important It is possible that the main title of the report Limb-Girdle Muscular Dystrophies is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
pelvofemoral muscular dystrophy
proximal muscular dystrophy
Limb-girdle muscular dystrophies (LGMD) are a group of rare progressive genetic disorders that are characterized by wasting (atrophy) and weakness of the voluntary muscles of the hip and shoulder areas (limb-girdle area). Muscle weakness and atrophy are progressive and may spread to affect other muscles of the body. Many different subtypes have been identified based upon abnormal changes (mutations) of certain genes. The age at onset, severity, and progression of symptoms of these subtypes may vary greatly from case to case, even among individuals in the same family. Some individuals may have a mild, slowly progressive form of the disorders; other may have a rapidly progressive form of the disorder that causes severe disability.
The term limb-girdle muscular dystrophies is a general term that encompasses several disorders. These disorders can now be distinguished by genetic and protein analysis. The various forms of LGMD may be inherited as autosomal dominant or recessive traits. Autosomal dominant LGMD is known as LGMD1 and there are currently recognized eight subtypes (LGMD1A-1H). Autosomal recessive LGMD is known as LGMD2 and has 17 subtypes (LGMDA-Q).
Additional terminology has been used in the past to describe forms of muscular dystrophy that are now classified under LGMD. These terms are no longer widely used and include scapulohumeral (Erb) muscular dystrophy, pelvifemoral (Leyden-Mobius) muscular dystrophy, and severe childhood autosomal recessive muscular dystrophy (SCARMD).
Muscular Dystrophy Association 3300 East Sunrise Drive Tucson, AZ 85718-3208 USA Tel: (520)529-2000 Fax: (520)529-5300 Tel: (800)572-1717 Email: email@example.com Internet: http://www.mda.org/
Muscular Dystrophy Campaign 61 Southwark Street London, SE1 0HL United Kingdom Tel: 02078034800 Email: firstname.lastname@example.org Internet: http://www.muscular-dystrophy.org
NIH/National Institute of Neurological Disorders and Stroke P.O. Box 5801 Bethesda, MD 20824 Tel: (301)496-5751 Fax: (301)402-2186 Tel: (800)352-9424 TDD: (301)468-5981 Internet: http://www.ninds.nih.gov/
Society for Muscular Dystrophy Information International P.O. Box 7490 Bridgewater Nova Scotia, B4V 2X6 Canada Tel: 9026853961 Fax: 9026853962 Email: email@example.com Internet: http://www.nsnet.org/smdi/
New Horizons Un-Limited, Inc. 811 East Wisconsin Ave P.O. Box 510034 Milwaukee, WI 53203 USA Tel: (414)299-0124 Fax: (414)347-1977 Email: firstname.lastname@example.org Internet: http://www.new-horizons.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
Let Them Hear Foundation 1900 University Avenue, Suite 101 East Palo Alto, CA 94303 Tel: (650)462-3174 Fax: (650)462-3144 Email: email@example.com Internet: http://www.letthemhear.org
Jain Foundation Inc. 2310 130th Avenue NE Suite B101 Bellevue, WA 98005 Tel: (425)882-1492 Fax: (240)282-0510 Email: firstname.lastname@example.org Internet: http://www.jain-foundation.org
Child Neurology Foundation 201 Chicago Ave, #200 Minneapolis, MN 55415 USA Tel: (952)641-6100 Fax: (952)881-6276 Tel: (877)263-5430 Email: email@example.com Internet: http://www.childneurologyfoundation.org
LGMD2I Research Fund PO Box 245 Bellevue, WA 98009 Tel: (425)460-2554 Fax: (425)460-1236 Email: firstname.lastname@example.org Internet: http://www.lgmd2ifund.org
Global FKRP Registry TREAT-NMD Office Institute of Genetic Medicine Newcastle University International Centre for Life Newcastle upon Tyne, NE1 3BZ United Kingdom Tel: 4401912418617 Fax: 4401912418770 Email: email@example.com Internet: https://www.fkrp-registry.org/
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
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Last Updated: 10/23/2012 Copyright 1992, 1994, 1994, 1999, 2000, 2012 National Organization for Rare Disorders, Inc.
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