Important It is possible that the main title of the report Agammaglobulinemia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
X-linked agammaglobulinemia (XLA)
X-linked agammaglobulinemia with growth hormone deficiency
autosomal recessive agammaglobulinemia
Agammaglobulinemia is a group of inherited immune deficiencies characterized by a low concentration of antibodies in the blood due to the lack of particular lymphocytes in the blood and lymph. Antibodies are proteins (immunoglobulins, (IgM), (IgG) etc) that are critical and key components of the immune system. They are essential if the immune system is to do its job of fighting off bacteria, viruses, and other foreign substances that threaten the body. The specialized precursor cells that produce gammaglobulins, fail to develop or function properly leading to the deficiency in the number of mature lymphocyte cells called B cells.
The types of agammaglobulinemia are: X-linked agammaglobulinemia (XLA), the much rarer X-linked agammaglobulinemia with growth hormone deficiency (about 10 cases reported), and autosomal recessive agammaglobulinemia (ARAG). All of these disorders are characterized by a weakened immune system that must be strengthened by the administration of gammaglobulin in order to fight off infections.
March of Dimes Birth Defects Foundation 1275 Mamaroneck Avenue White Plains, NY 10605 Tel: (914)997-4488 Fax: (914)997-4763 Tel: (888)663-4637 Email: Askus@marchofdimes.com Internet: http://www.marchofdimes.com
Immune Deficiency Foundation 40 W. Chesapeake Avenue Suite 308 Towson, MD 21204 Tel: (410)321-6647 Fax: (410)321-9165 Tel: (800)296-4433 Email: email@example.com Internet: http://www.primaryimmune.org
Centers for Disease Control and Prevention 1600 Clifton Road NE Atlanta, GA 30333 Tel: (404)639-3534 Tel: (800)232-4636 TDD: (888)232-6348 Email: firstname.lastname@example.org Internet: http://www.cdc.gov/
NIH/National Institute of Allergy and Infectious Diseases Office of Communications and Government Relations 6610 Rockledge Drive, MSC 6612 Bethesda, MD 20892-6612 Tel: (301)496-5717 Fax: (301)402-3573 Tel: (866)284-4107 TDD: (800)877-8339 Email: email@example.com Internet: http://www.niaid.nih.gov/
American Academy of Allergy, Asthma and Immunology 611 East Wells Street Milwaukee, WI 53202 Tel: (414)272-6071 Fax: (414)276-3349 Tel: (800)822-2762 Email: firstname.lastname@example.org Internet: http://www.aaaai.org
International Patient Organization for Primary Immunodeficiencies Firside Main Road Downderry Cornwall, PL11 3LE United Kingdom Tel: 441503250668 Fax: 441503250961 Email: email@example.com Internet: http://www.ipopi.org/
Jeffrey Modell Foundation 780 Third Avenue New York, NY 10017 USA Tel: (212)819-0200 Fax: (212)764-4180 Tel: (866)469-6474 Email: firstname.lastname@example.org Internet: http://www.info4pi.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
Madisons Foundation PO Box 241956 Los Angeles, CA 90024 Tel: (310)264-0826 Fax: (310)264-4766 Email: email@example.com Internet: http://www.madisonsfoundation.org
Autoimmune Information Network, Inc. PO Box 4121 Brick, NJ 08723 Fax: (732)543-7285 Email: firstname.lastname@example.org
European Society for Immunodeficiencies 1-3 rue de Chantepoulet Geneva, CH 1211 Switzerland Tel: 410229080484 Fax: 41229069140 Email: email@example.com Internet: http://www.esid.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email firstname.lastname@example.org
Last Updated: 6/16/2010 Copyright 1986, 1987, 1988, 1989, 1993, 1996, 1998, 1999, 2001, 2007, 2009, 2010 National Organization for Rare Disorders, Inc.
How this information was developed to help you make better health decisions.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.