Important It is possible that the main title of the report Agammaglobulinemia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
X-linked agammaglobulinemia (XLA)
X-linked agammaglobulinemia with growth hormone deficiency
autosomal recessive agammaglobulinemia
Agammaglobulinemia is a group of inherited immune deficiencies characterized by a low concentration of antibodies in the blood due to the lack of particular lymphocytes in the blood and lymph. Antibodies are proteins (immunoglobulins, (IgM), (IgG) etc) that are critical and key components of the immune system. They are essential if the immune system is to do its job of fighting off bacteria, viruses, and other foreign substances that threaten the body. The specialized precursor cells that produce gammaglobulins, fail to develop or function properly leading to the deficiency in the number of mature lymphocyte cells called B cells.
The types of agammaglobulinemia are: X-linked agammaglobulinemia (XLA), the much rarer X-linked agammaglobulinemia with growth hormone deficiency (about 10 cases reported), and autosomal recessive agammaglobulinemia (ARAG). All of these disorders are characterized by a weakened immune system that must be strengthened by the administration of gammaglobulin in order to fight off infections.
March of Dimes Birth Defects Foundation 1275 Mamaroneck Avenue White Plains, NY 10605 Tel: (914)997-4488 Fax: (914)997-4763 Tel: (888)663-4637 Email: Askus@marchofdimes.com Internet: http://www.marchofdimes.com
Immune Deficiency Foundation 40 W. Chesapeake Avenue Suite 308 Towson, MD 21204 Tel: (410)321-6647 Fax: (410)321-9165 Tel: (800)296-4433 Email: firstname.lastname@example.org Internet: http://www.primaryimmune.org
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International Patient Organization for Primary Immunodeficiencies Firside Main Road Downderry Cornwall, PL11 3LE United Kingdom Tel: 441503250668 Fax: 441503250961 Email: firstname.lastname@example.org Internet: http://www.ipopi.org/
Jeffrey Modell Foundation 780 Third Avenue New York, NY 10017 USA Tel: (212)819-0200 Fax: (212)764-4180 Tel: (866)469-6474 Email: email@example.com Internet: http://www.info4pi.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
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Autoimmune Information Network, Inc. PO Box 4121 Brick, NJ 08723 Fax: (732)543-7285 Email: email@example.com
European Society for Immunodeficiencies 1-3 rue de Chantepoulet Geneva, CH 1211 Switzerland Tel: 410229080484 Fax: 41229069140 Email: firstname.lastname@example.org Internet: http://www.esid.org
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