Important It is possible that the main title of the report Multiple Sclerosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Primary Progressive Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Multiple sclerosis is a chronic neuroimmunologic (both the nervous system and the immunological system are involved) disorder of the central nervous system involving the brain, spinal chord and optic nerves. By means of a mechanism not clearly understood, the protective fatty, insulating substance called myelin sheath that covers the nerve is destroyed. The inflammatory attacks that produce the characteristic scarring (plaques or patches) of the myelin sheath occur randomly, vary in intensity, and at multiple sites. The course of the disease may advance, relapse, remit, or stabilize. The randomness of the location of plaques or patches affects the nerve's ability to transmit information (neurotransmission) and causes a wide range of neurological symptoms, which may vary from person to person.
Recently it has been learned that the nerve fibers themselves, (axons), in addition to the myelin sheaths, are affected by the neuroimmunologic attacks. Damage to the nerve cells may be irreversible. As a result, clinicians recommend early intervention with one of the disease-modifying agents (see below).
WE MOVE (Worldwide Education and Awareness for Movement Disorders) 5731 Mosholu Avenue Bronx, NY 10471 USA Tel: (347)843-6132 Fax: (718)601-5112 Email: firstname.lastname@example.org Internet: http://www.wemove.org
National Multiple Sclerosis Society 1100 New York Avenue NW Suite 660 Washington, D.C. 20005-3934 USA Tel: (202)408-1500 Fax: (202)408-0696 Tel: (800)344-4867 Email: David.Chatel@nmss.org Internet: http://www.nationalmssociety.org
American Autoimmune Related Diseases Association, Inc. 22100 Gratiot Ave. East Detroit, MI 48021 Tel: (586)776-3900 Fax: (586)776-3903 Tel: (800)598-4668 Email: email@example.com Internet: http://www.aarda.org/
NIH/National Institute of Neurological Disorders and Stroke P.O. Box 5801 Bethesda, MD 20824 Tel: (301)496-5751 Fax: (301)402-2186 Tel: (800)352-9424 TDD: (301)468-5981 Email: firstname.lastname@example.org Internet: http://www.ninds.nih.gov/
Consortium of Multiple Sclerosis Centers 359 Main Street Suite A Hackensack, NJ 07601 Tel: (201)487-1050 Fax: (201)678-2290 Email: email@example.com Internet: http://www.mscare.org
Multiple Sclerosis Association of America 706 Haddonfield Road Cherry Hill, NJ 08002 USA Tel: (856)488-4500 Fax: (856)661-9797 Tel: (800)532-7667 Email: firstname.lastname@example.org Internet: http://www.msassociation.org/
Multiple Sclerosis International Federation 3rd Floor Skyline House 200 Union Street London, Intl SE1 0LX United Kingdom Tel: +44 (0)20 7620 1911 Fax: +44 (0)20 7620 1922 Email: email@example.com Internet: http://www.msif.org
Spastic Paraplegia Foundation 7700 Leesburg Pike, Ste 123 Falls Church, VA 22043 USA Tel: (877)773-4483 Email: firstname.lastname@example.org Internet: http://sp-foundation.org
Vasculitis of the Central Nervous System vasculitisoftheCNS@yahoogroups.com Tel: (770)978-5636 Email: email@example.com Internet: http://www.VasculitisoftheCNS@yahoogroups.com
MUMS National Parent-to-Parent Network 150 Custer Court Green Bay, WI 54301-1243 USA Tel: (920)336-5333 Fax: (920)339-0995 Tel: (877)336-5333 Email: firstname.lastname@example.org Internet: http://www.netnet.net/mums/
Christopher Reeve Paralysis Foundation 636 Morris Turnpike, Suite 3A Short Hills, NJ 07078 USA Tel: (973)379-2690 Fax: (973)912-9433 Tel: (800)225-0292 Email: prc@ChristopherReeve.org Internet: http://www.christopherreeve.org
New Horizons Un-Limited, Inc. 811 East Wisconsin Ave P.O. Box 510034 Milwaukee, WI 53203 USA Tel: (414)299-0124 Fax: (414)347-1977 Email: email@example.com Internet: http://www.new-horizons.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
Madisons Foundation PO Box 241956 Los Angeles, CA 90024 Tel: (310)264-0826 Fax: (310)264-4766 Email: firstname.lastname@example.org Internet: http://www.madisonsfoundation.org
Autoimmune Information Network, Inc PO Box 4121 Brick, NJ 08723 Fax: (732)543-7285 Email: email@example.com
European Society for Immunodeficiencies 1-3 rue de Chantepoulet Geneva, CH 1211 Switzerland Tel: +31 73-6992965 Fax: +41 22 906 91 40 Email: firstname.lastname@example.org Internet: http://www.esid.org
Multiple Sclerosis Foundation 6520 North Andrews Avenue Ft. Lauderdale, FL 33309-2130 Tel: (954)776-6805 Fax: (954)938-8708 Tel: (800)225-6495 Email: email@example.com Internet: http://www.msfocus.org
American Association of Neurological Surgeons 5550 Meadowbrook Drive Rolling Meadows, IL 60008-3852 Tel: (847)378-0500 Fax: (847)378-0600 Tel: (888)566-2267 Email: firstname.lastname@example.org Internet: http://www.NeurosurgeryToday.org and http://www.aans.org
AutoImmunity Community Email: email@example.com Internet: http://www.autoimmunitycommunity.org
PLAN Institute for Caring Citizenship Suite 260 - 3665 Kingsway Vancouver British Columbia, V5R 5W2 Canada Tel: 604-439-9566 Fax: 604-439-7001 Email: firstname.lastname@example.org Internet: http://www.planinstitute.ca/?q=learnfromus/library
Child Neurology Foundation 2000 West 98th Street Bloomington, MN 55431 USA Tel: (952)641-6100 Fax: (952)881-6276 Tel: (877)263-5430 Email: email@example.com Internet: http://www.childneurologyfoundation.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email firstname.lastname@example.org
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