Important It is possible that the main title of the report Autosomal Dominant Polycystic Kidney Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the formation of cysts within the kidneys. Symptoms caused by cyst formation in the kidneys include high blood pressure (hypertension), pain on the sides of the body between the last rib and the hip (flank pain), blood in the urine (hematuria) and progressively poor function of the kidneys (kidney insufficiency). In approximately 60 percent of cases, ADPKD eventually progresses to cause end stage renal disease, requiring renal replacement therapy, either dialysis or renal transplantation. ADPKD is not simply a kidney disorder and other organ systems of the body can potentially be affected (multisystem disorder) by the development of cysts. The specific symptoms present in each person depend upon the specific organ systems involved. The liver, pancreas, a membrane covering the spinal cord and brain (arachnoid membrane), the prostate, and the glands of the male reproductive tract that produce fluid that is part of semen (seminal vesicles) may become involved. Abnormalities affecting the heart and blood vessels (cardiovascular system) may also occur in individuals with ADPKD. ADPKD usually does not become apparent until the fourth or fifth decade and was once known as "adult" polycystic kidney disease. However, it has been reported in children and infants. ADPKD is caused by mutations of one of two genes that create certain proteins essential for the proper health of the kidneys and other parts of the body. Approximately 85 % have ADPKD1, the most aggressive form of the disease; those with ADPKD2 progress to kidney insufficiency about 20 years later.
American Association of Kidney Patients 2701 North Rocky Point Drive, Suite 150 Tampa, FL 33607 USA Tel: (813)636-8100 Fax: (813)636-8122 Tel: (800)749-2257 Email: email@example.com Internet: http://www.aakp.org
American Kidney Fund, Inc. 11921 Rockville Pike Suite 300 Rockville, MD 20852 USA Tel: (800)638-8299 Email: firstname.lastname@example.org Internet: http://www.kidneyfund.org
National Kidney Foundation 30 East 33rd Street New York, NY 10016 Tel: (212)889-2210 Fax: (212)689-9261 Tel: (800)622-9010 Email: email@example.com Internet: http://www.kidney.org
PKD Foundation 8330 Ward Parkway Suite 510 Kansas City, MO 64114-2000 USA Tel: (816)931-2600 Fax: (816)931-8655 Tel: (800)753-2873 Email: firstname.lastname@example.org Internet: http://www.pkdcure.org
NIH/National Kidney and Urologic Diseases Information Clearinghouse 3 Information Way Bethesda, MD 20892-3580 Fax: (703)738-4929 Tel: (800)891-5390 TDD: (866)569-1162 Email: email@example.com Internet: http://www.kidney.niddk.nih.gov/
National Hypertension Association, Inc. 324 East 30th Street New York, NY 10016 Tel: (212)889-3557 Fax: (212)447-7032 Tel: (800)575-9355 Email: firstname.lastname@example.org Internet: http://www.nathypertension.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
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Last Updated: 8/2/2012 Copyright 2009, 2012 National Organization for Rare Disorders, Inc.
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