Important It is possible that the main title of the report Cutaneous T-Cell Lymphomas is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Granulomatous Slack Skin
Primary Cutaneous Anaplastic Large Cell Lymphomas
Subcutaneous Panniculitic T-Cell Lymphoma
Pagetoid Reticulosis (Woringer-Kolopp Disease)
Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by abnormal accumulation of malignant T-cells in the skin potentially resulting in the development of rashes, plaques and tumors. CTCLs belong to a larger group of disorders known as non-Hodgkin's lymphomas (NHLs), which are related malignancies (cancers) that affect the lymphatic system (lymphomas). Functioning as part of the immune system, the lymphatic system helps to protect the body against infection and disease. It consists of a network of tubular channels (lymph vessels) that drain a thin watery fluid known as lymph from different areas of the body into the bloodstream. Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes.
There are two main types of lymphocytes: B-lymphocytes, which may produce specific antibodies to "neutralize" certain invading microorganisms, and T-lymphocytes, which may directly destroy microorganisms or assist in the activities of other lymphocytes. CTCLs result from errors in the production of T-lymphocytes or transformation of T-lymphocytes into malignant cells. In CTCLs abnormal, uncontrolled growth and multiplication (proliferation) of malignant T-lymphocytes result in accumulation of these lymphocytes in the skin. In some cases, malignant lymphocytes may spread to affect the lymph nodes and eventually to other bodily tissues and organs, potentially resulting in life-threatening complications. The specific symptoms and physical findings may vary from case to case, depending upon the extent and region(s) of involvement, the specific type of CTCL present, and various additional factors.
Non-Hodgkin's lymphomas, such as CTCLs, may also be categorized based upon certain characteristics of the cancer cells as seen under a microscope and how quickly they may tend to grow and spread. For example, CTCLs may be characterized as "low-grade" (or indolent) lymphomas, which tend to grow slowly and result in few associated symptoms, or "intermediate-grade" or "high-grade" (aggressive) lymphomas, which typically grow rapidly, requiring prompt treatment. Most cases of CTCL, especially the classic form (mycosis fungoides), are slow-growing (indolent) lymphomas.
Leukemia & Lymphoma Society 1311 Mamaroneck Avenue Suite 310 White Plains, NY 10605 Tel: (914)949-5213 Fax: (914)949-6691 Tel: (800)955-4572 Email: infocenter@LLS.org Internet: http://www.LLS.org
American Cancer Society, Inc. 250 Williams NW St Ste 6000 Atlanta, GA 30303 USA Tel: (404)320-3333 Tel: (800)227-2345 TDD: (866)228-4327 Internet: http://www.cancer.org
National Cancer Institute Physician Data Query Office of Communications and Education Public Inquiries Office 6116 Executive Blvd Suite 300 Bethesda, MD 20892-8322 Tel: (800)422-6237 Email: firstname.lastname@example.org Internet: http://www.cancer.gov/cancertopics/pdq/cancerdatabase
National Cancer Institute 6116 Executive Blvd Suite 300 Bethesda, MD 20892-8322 USA Tel: (301)435-3848 Tel: (800)422-6237 TDD: (800)332-8615 Email: email@example.com Internet: http://www.cancer.gov
National Coalition for Cancer Survivorship 1010 Wayne Avenue 7th Floor Silver Spring, MD 20910 Tel: (301)650-9127 Fax: (301)565-9670 Tel: (888)650-9127 Email: firstname.lastname@example.org Internet: http://www.canceradvocacy.org/
Cancer Hope Network 2 North Road Suite A Chester, NJ 07930 Tel: (908)879-4039 Fax: (908)879-6518 Tel: (800)552-4366 Email: email@example.com Internet: http://www.cancerhopenetwork.org
OncoLink: The University of Pennsylvania Cancer Center Resource 3400 Spruce Street 2 Donner Philadelphia, PA 19104-4283 USA Tel: (215)349-8895 Fax: (215)349-5445 Email: firstname.lastname@example.org Internet: http://www.oncolink.upenn.edu
Lymphoma Research Foundation 115 Broadway Suite 1301 New York, NY 10006 USA Tel: (212)349-2910 Fax: (212)349-2886 Tel: (800)235-6848 Email: LRF@lymphoma.org Internet: http://www.lymphoma.org
Canadian Cancer Society 55 St. Clair Avenue West Suite 500 Toronto, M4V 2Y7 Canada Tel: 4164885400 Fax: 4164882872 Tel: 8002688874 Email: email@example.com Internet: http://www.cancer.ca/
Lymphoma Association (UK) PO Box 386 Aylesbury, HP20 2GA United Kingdom Tel: 01296619400 Email: firstname.lastname@example.org Internet: www.lymphomas.org.uk
International Cancer Alliance for Research and Education (ICARE) 4853 Cordell Avenue Suite 14 Bethesda, MD 20814 Tel: (301)656-3461 Fax: (301)654-8684 Tel: (800)422-7361 Email: email@example.com Internet: http://www.icare.org
Rare Cancer Alliance 1649 North Pacana Way Green Valley, AZ 85614 USA Internet: http://www.rare-cancer.org
Cutaneous Lymphoma Foundation PO Box 374 Birmingham, MI 48012-0374 USA Tel: (248)644-9014 Fax: (248)233-3769 Email: firstname.lastname@example.org Internet: http://www.clfoundation.org
Genetic and Rare Diseases (GARD) Information Center PO Box 8126 Gaithersburg, MD 20898-8126 Tel: (301)251-4925 Fax: (301)251-4911 Tel: (888)205-2311 TDD: (888)205-3223 Internet: http://rarediseases.info.nih.gov/GARD/
Friends of Cancer Research 1800 M Street NW Suite 1050 South Washington, DC 22202 Tel: (202)944-6700 Email: email@example.com Internet: http://www.focr.org
Cancer Support Community 1050 17th St NW Suite 500 Washington, DC 20036 Tel: (202)659-9709 Fax: (202)974-7999 Tel: (888)793-9355 Internet: http://www.cancersupportcommunity.org/
Lance Armstrong Foundation 2201 E. Sixth Street Austin, TX 78702 Tel: (512)236-8820 Fax: (512)236-8482 Tel: (877)236-8820 Email: firstname.lastname@example.org Internet: http://www.livestrong.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 1/3/2007 Copyright 1989, 1996, 1997, 1998, 2002, 2003, 2007 National Organization for Rare Disorders, Inc.
How this information was developed to help you make better health decisions.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.